Pain & Inflammation
Cannabis & Chronic Pain: What the Clinical Research Shows
States with medical cannabis laws show real differences in opioid mortality. What 30+ clinical trials say about cannabis for chronic pain management.
Mental Health
Cannabis & PTSD: Evidence From VA Studies and Clinical Trials
VA-backed clinical trials and patient surveys have produced some of the most compelling evidence for cannabis in mental health — specifically PTSD.
Neurology
CBD & Epilepsy: From University Labs to FDA Approval
The clinical trials that led the FDA to approve Epidiolex in 2018 — and what they mean for other neurological conditions.
The Science
The Endocannabinoid System: The Science Behind Why Cannabis Works
Every mammal has an endocannabinoid system. Understanding it is the key to understanding why cannabis has such wide-ranging effects on the body and mind.
Neurology
Cannabis & Multiple Sclerosis: What the Research Shows
Nabiximols (Sativex) is approved in 29 countries for MS spasticity. Here's the clinical trial evidence behind that approval and what it means.
Mental Health
Cannabis & Anxiety: What Clinical Studies Actually Show
CBD has shown meaningful anxiolytic effects in controlled trials. THC's relationship with anxiety is more complex — and dose-dependent.
Cancer Care
Medical Cannabis in Cancer Care: Symptom Management Evidence
From FDA-approved dronabinol to whole-plant cannabis — four decades of evidence for cannabis in managing cancer symptoms.
Mental Health
Cannabis & Sleep: Clinical Research on Insomnia and Sleep Disorders
Cannabis consistently improves sleep onset and deep sleep in the short term. What happens with long-term use is more complicated.
Pain & Inflammation
CBD & Inflammation: Mechanisms and Clinical Evidence
CBD modulates multiple inflammatory pathways. Transdermal arthritis studies and cytokine research point toward real clinical potential.
Neurology
Cannabis & Parkinson's Disease: Research on Symptoms and Quality of Life
Israeli clinical trials and observational studies show cannabis improves motor function and quality of life in Parkinson's patients.
Pain & Inflammation
Cannabis & Crohn's Disease: What Clinical Trials Have Found
Small but well-designed trials show cannabis reduces Crohn's disease activity — though the path to remission remains less clear.
The Science
How THC Works: The Neuroscience of Cannabis Intoxication
From Mechoulam's 1964 discovery of THC to modern CB1 receptor mapping — the complete pharmacology of cannabis intoxication.
The Science
The Science of CBD: How It Works and What the Evidence Shows
CBD works through at least a dozen molecular targets — none of them the CB1 receptor. Here's the complete mechanism science.
Pain & Inflammation
Cannabis & the Opioid Crisis: What Population Data Reveals
A landmark JAMA Internal Medicine study found 24.8% lower opioid overdose mortality in states with medical cannabis laws.
Mental Health
Cannabis & Depression: Complex Findings From Clinical Research
The same endocannabinoid system that regulates mood can be disrupted by heavy cannabis use. The honest picture is complicated.
The Science
Terpene Science: Beyond THC and CBD
Beta-caryophyllene directly activates CB2 receptors — making it a dietary cannabinoid. The science behind cannabis terpenes.
Pain & Inflammation
Cannabis & Athletic Recovery: Sports Medicine Research
WADA removed CBD from banned substances in 2018. What the evidence says about cannabis for athletic recovery and pain.
Neurology
Cannabis & Alzheimer's Disease: Promising Research, Real Limitations
THC inhibits amyloid aggregation in the lab. But clinical evidence in Alzheimer's patients remains thin and the safety risks are real.
The Science
Cannabis Dosing Research: The Science of Finding Your Therapeutic Window
Cannabis has a biphasic dose-response curve — the dose that relieves anxiety and the dose that triggers it can be closer than expected.
Cancer Care
Cannabis for Nausea and Appetite: Four Decades of Clinical Evidence
Synthetic THC has been FDA-approved for chemotherapy nausea since 1985. Here's 40 years of clinical evidence in oncology and AIDS care.
Pain & Inflammation
Cannabis & Diabetes: What Research Says About Blood Sugar and Metabolic Health
Cannabis users show lower fasting insulin and smaller waist circumference in large population studies. What the metabolic research actually shows — and the caveats.
Women's Health
Cannabis & Women's Health: Menstrual Pain, Menopause, and Reproductive Research
From dysmenorrhea to menopause symptom relief, cannabis research is catching up to what millions of women already report. Here's what the clinical evidence shows so far.
Neurology
Cannabis & Autism Spectrum Disorder: Early Clinical Trials and Parental Reports
Israeli researchers published some of the first controlled data on CBD for ASD behavioral symptoms. What the preliminary evidence shows — and why caution is still warranted.
Aging & Longevity
Cannabis & the Aging Brain: Neuroprotection, Cognitive Risk, and the Senior Boom
Cannabis use among adults 65+ has tripled since 2015. Researchers are racing to understand what that means for cognition, neurodegeneration, and quality of life.
The Science
THC vs. CBD: Clinical Differences, Mechanisms, and What Research Recommends
Same plant, radically different pharmacology. A deep dive into how THC and CBD interact with the endocannabinoid system differently — and what that means clinically.
Pain & Inflammation
Cannabis & Glaucoma: Why the Research Is More Complicated Than It Looks
Cannabis does reduce intraocular pressure — but only for 3–4 hours. Ophthalmology researchers explain why that makes it a poor fit for glaucoma management as currently understood.
Mental Health
Microdosing Cannabis: What the Clinical Evidence Actually Shows
Sub-perceptual THC doses are being studied for anxiety, focus, and mood. Separating the hype from what peer-reviewed research has actually documented so far.
The Science
Cannabis & Heart Health: Cardiovascular Benefits, Risks, and the Research Divide
CBD shows anti-inflammatory promise for cardiovascular disease while heavy THC use is linked to elevated heart rate and rare adverse events. A balanced look at the cardiac evidence.
Mental Health
Cannabis Use Disorder: What Research Says About Dependence, Withdrawal, and Risk Factors
About 9% of cannabis users develop dependence — lower than alcohol, tobacco, or opioids, but real. Clinical research on who is most at risk and what treatment evidence exists.
Aging & Longevity
Cannabis for Seniors: Pain, Sleep, and Palliative Care Research in Older Adults
The fastest-growing cannabis demographic is adults over 60. Clinical research on dosing considerations, drug interactions, and efficacy for age-related conditions.